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Clinical Trials & Approval The clinical development phase begins with Investigational New Drug (IND) submissions and proceeds through Phase I trials for safety and pharmacokinetics, Phase II for dose optimization and early efficacy, and Phase III for large-scale confirmation of therapeutic benefits

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Using a technique called target trial emulation, which is designed to mimic the structure of a randomised trial using real-world data, they compared patients starting a GLP-1 medication with patients starting two other classes of diabetes drug: SGLT2 inhibitors and DPP4 inhibitors

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